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COMPLETED Phase 1

Safety and Pharmacokinetics (PK) of Escalating Doses of Tiragolumab as a Single Agent and in Combination With Atezolizumab and/or Other Anti-Cancer Therapies in Locally Advanced or Metastatic Tumors

NCT02794571 · View on ClinicalTrials.gov ↗

Study Summary

This first-in-human open-label, multicenter, dose-escalation and expansion study is designed to evaluate the safety, tolerability, and PK of tiragolumab alone or in combination with atezolizumab and/or other anti-cancer therapies in participants with locally advanced, recurrent, or metastatic incurable tumors for whom standard therapy does not exist, has proven to be ineffective or intolerable, or is considered inappropriate, or for whom a clinical trial of an investigational agent is a recognized standard of care.

Conditions Studied

Interventions

  • DRUG Carboplatin
  • DRUG Atezolizumab
  • DRUG Cisplatin
  • DRUG Pemetrexed
  • DRUG Tiragolumab

Study Locations (20)

Other

  • Institut Bergonie CLCC Bordeaux — Bordeaux
  • Centre Léon Bérard Centre Régional de Lutte Contre Le Cancer Rhône Alpes — Lyon
  • Institut Curie — Paris
  • Institut Claudius Regaud; Departement Oncologie Medicale — Toulouse
  • Institut Gustave Roussy — Villejuif
  • National Cancer Center Hospital — Tokyo
  • The Cancer Institute Hospital of Japanese Foundation For Cancer Research — Tokyo
  • Seoul National University Hospital — Seoul
  • Severance Hospital, Yonsei University Health System — Seoul

Arizona

  • Honor Health Research Institute — Scottsdale

California

  • University of California Los Angeles — Santa Monica

Connecticut

  • Yale Cancer Center — New Haven

Maryland

  • Johns Hopkins Sidney Kimmel Comprehensive Cancer Center — Baltimore

Massachusetts

  • Dana Farber Cancer Institute — Boston

Michigan

  • Henry Ford Hospital — Detroit

New York

  • Memorial Sloan-Kettering Cancer Center — New York

Trial Details

FieldValue
Enrollment Target 518 participants
Start Date 2016-05-23
Est. Completion 2024-11-13
Phase Phase 1

Sponsor

Genentech

206 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02794571

The ClinicalTrials.gov registry entry for NCT02794571 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 518 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Genentech, which has 206 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Advanced/Metastatic Tumors appearing as the primary indexed condition, and to 5 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02794571 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Other, Arizona, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02794571 about?

NCT02794571 is a clinical study titled "Safety and Pharmacokinetics (PK) of Escalating Doses of Tiragolumab as a Single Agent and in Combination With Atezolizumab and/or Other Anti-Cancer Therapies in Locally Advanced or Metastatic Tumors". This first-in-human open-label, multicenter, dose-escalation and expansion study is designed to evaluate the safety, tolerability, and PK of tiragolumab alone or in combination with atezolizumab and/or other anti-cancer therapies in participants with locally advanced, recurrent, or metastatic incura...

What is the current status of trial NCT02794571?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 518 participants. The study started on 2016-05-23. Estimated completion is 2024-11-13.

What conditions does trial NCT02794571 study?

This clinical trial studies the following conditions: Advanced/Metastatic Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02794571?

The interventions under investigation include: Carboplatin (DRUG), Atezolizumab (DRUG), Cisplatin (DRUG), Pemetrexed (DRUG), Tiragolumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02794571?

This trial is sponsored by Genentech, which has 206 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02794571 being conducted?

This trial has 20 study locations across Arizona, California, Connecticut, Maryland, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial