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A Study to Determine Dose, Safety, Tolerability and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Subjects With Multiple Myeloma
NCT02773030 · View on ClinicalTrials.gov ↗
Study Summary
This is a multicenter, multi-country, open-label, Phase 1b/2a dose-escalation study consisting of two parts: dose escalation (Part 1) for CC-220 monotherapy, CC-220 in combination with DEX, CC-220 in combination with DEX and DARA, CC-220 in combination with DEX and BTZ and CC-220 in combination with DEX and CFZ; and the expansion of the RP2D (Part 2) for CC-220 in combination with DEX for Relapsed Refractory Multiple Myeloma and CC-220 in combination with DEX and BTZ for Newly Diagnosed Multiple Myeloma.
Conditions Studied
Interventions
- DRUG Dexamethasone
- DRUG Daratumumab
- DRUG Carfilzomib
- DRUG Bortezomib
- DRUG CC-220
Study Locations (20)
Massachusetts
- Beth Israel Deaconess Medical Center — Boston
- Local Institution - 114 — Boston
- Local Institution - 115 — Boston
- Massachusetts General Hospital — Boston
- Dana-Farber/Mass General Brigham Cancer Care, Inc — Boston
- Local Institution - 110 — Boston
Arizona
- Local Institution - 102 — Scottsdale
- Mayo Clinic — Scottsdale
Arkansas
- Local Institution - 107 — Little Rock
- University of Arkansas for Medical Sciences — Little Rock
Georgia
- Local Institution - 101 — Atlanta
- Winship Cancer Institute of Emory University — Atlanta
Illinois
- Local Institution - 120 — Chicago
- Robert H Lurie Comprehensive Cancer Center NW Univ — Chicago
Kansas
- Local Institution - 113 — Fairway
- University of Kansas Cancer Center — Fairway
Maryland
- Local Institution - 106 — Baltimore
- University of Maryland School of Med — Baltimore
Michigan
- Local Institution - 104 — Ann Arbor
- University of Michigan Comprehensive Cancer Center — Ann Arbor
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 466 participants |
| Start Date | 2016-10-14 |
| Est. Completion | 2028-07-28 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02773030
The ClinicalTrials.gov registry entry for NCT02773030 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 466 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Celgene, which has 73 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Multiple Myeloma appearing as the primary indexed condition, and to 5 interventions — of which Dexamethasone is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT02773030 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Massachusetts, Arizona, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT02773030 about?
NCT02773030 is a clinical study titled "A Study to Determine Dose, Safety, Tolerability and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Subjects With Multiple Myeloma". This is a multicenter, multi-country, open-label, Phase 1b/2a dose-escalation study consisting of two parts: dose escalation (Part 1) for CC-220 monotherapy, CC-220 in combination with DEX, CC-220 in combination with DEX and DARA, CC-220 in combination with DEX and BTZ and CC-220 in combination with...
What is the current status of trial NCT02773030?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 466 participants. The study started on 2016-10-14. Estimated completion is 2028-07-28.
What conditions does trial NCT02773030 study?
This clinical trial studies the following conditions: Multiple Myeloma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT02773030?
The interventions under investigation include: Dexamethasone (DRUG), Daratumumab (DRUG), Carfilzomib (DRUG), Bortezomib (DRUG), CC-220 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT02773030?
This trial is sponsored by Celgene, which has 73 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT02773030 being conducted?
This trial has 20 study locations across Arizona, Arkansas, Georgia, Illinois, Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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