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A Multi-Center, Open-Label Study of Surufatinib (HMPL-012) in Patients With Advanced Solid Tumors
NCT02549937 · View on ClinicalTrials.gov ↗
Study Summary
Primary Objective Dose Escalation: To evaluate the safety and tolerability of surufatinib in patients with advanced solid tumors and to determine the maximum tolerable dose (MTD) or recommended phase II dose (RP2D). Primary Objective Dose Expansion: To evaluate the anticancer activity of surufatinib in patients with advanced Biliary Tract Cancer (BTC), patients with advanced pancreatic neuroendocrine tumors (pNETs), patients with locally advanced, unresectable, metastatic extra-pancreatic neuroendocrine tumors (EP-NETs), and patients with soft tissue sarcomas (STS) treated at a dose of 300 mg QD. Secondary Objective: To evaluate the pharmacokinetic profile of multiple dose surufatinib in patients with advanced solid tumors and to evaluate the anti cancer activity of surufatinib in patients with advanced solid tumors.
Conditions Studied
Interventions
- DRUG surufatinib
Study Locations (12)
Texas
- Mary Crowley Cancer Research Center — Dallas
- Baylor Charles A. Sammons Cancer Center — Dallas
- MD Anderson Cancer Center — Houston
Colorado
- Rocky Mountain Cancer Center — Denver
- SCRI at HealthONE — Denver
New York
- Mount Sinai Hospital — New York
- Memorial Sloan Kettering Cancer Center — New York
California
- City of Hope Comprehensive Cancer Center — Los Angeles
Florida
- Florida Cancer Specialists — Sarasota
Tennessee
- Tennessee Oncology — Nashville
Virginia
- Virginia Cancer Specialists, PC — Fairfax
Other
- Fondazione IRCCS Istituto Nazionale dei Tumori — Milan
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 130 participants |
| Start Date | 2015-11 |
| Est. Completion | 2023-06-02 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02549937
The ClinicalTrials.gov registry entry for NCT02549937 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 130 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hutchmed, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Tumors appearing as the primary indexed condition, and to 1 intervention — of which surufatinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT02549937 reports 12 study locations spanning 8 distinct geographic areas — top geographies include Texas, Colorado, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT02549937 about?
NCT02549937 is a clinical study titled "A Multi-Center, Open-Label Study of Surufatinib (HMPL-012) in Patients With Advanced Solid Tumors". Primary Objective Dose Escalation: To evaluate the safety and tolerability of surufatinib in patients with advanced solid tumors and to determine the maximum tolerable dose (MTD) or recommended phase II dose (RP2D). Primary Objective Dose Expansion: To evaluate the anticancer activity of surufati...
What is the current status of trial NCT02549937?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 130 participants. The study started on 2015-11. Estimated completion is 2023-06-02.
What conditions does trial NCT02549937 study?
This clinical trial studies the following conditions: Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT02549937?
The interventions under investigation include: surufatinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT02549937?
This trial is sponsored by Hutchmed, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT02549937 being conducted?
This trial has 12 study locations across California, Colorado, Florida, New York, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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