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NCT02020408 · ClinicalTrials.gov registry record · Phase 4
Monoamine Contributions to Neurocircuitry in Eating Disorders
A Phase 4 study of Eating Disorder, sponsored by University of California, San Diego.
- Completed
- Registry status
- Phase 4
- Development phase
- 88
- Enrollment target
- 1
- Study location
NCT02020408: Completed Phase 4 study of Eating Disorder, sponsored by University of California, San Diego.
NCT02020408 is a Phase 4 study of Eating Disorder that has completed, run by University of California, San Diego. The registered enrollment target is 88 participants, below the 110-participant average among 9 other Eating Disorder trials with a reported enrollment target (20% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02020408, a Phase 4 study of Eating Disorder, has completed, sponsored by University of California, San Diego.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 88 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will use brain imaging technologies to measure several neurotransmitters (serotonin and dopamine) that contribute to our abilities to respond to reward or inhibit our impulses, and which are known to be altered in the brain of people with anorexia nervosa (AN) and bulimia nervosa (BN). Because palatable food stimulates dopamine secretion, we propose to use a challenge with brain imaging that will stimulate dopamine release which we hypothesize will generate anxiety rather than pleasure in AN, and will help explain why AN restrict eating in order to reduce anxiety. This study will help to understand the unique puzzling symptoms in eating disorders and contribute to finding better methods for identifying effective treatments for these often relapsing and sometimes chronic disorders.
Primary Outcome
Use PET and \[11C\]DASB to explore 5-HTT receptor binding potential midbrain and striatal regions of interest in eating disorder subtypes. The Binding Potential (BP) was calculated as BP Non Displaceable (ND) = (VT/VND) -1. \[VT = distribution volume in tissue; VND = non-displaceable distribution volume\]. The binding of the 5-HTT on PET presumably reflects 5-HTT density and/or affinity.
Conditions Studied
Interventions
- DRUG [11C]raclopride
- DRUG [11C]DASB
- DRUG amphetamine
Study Locations (1)
California
- University of California San Diego - San Diego
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 88 participants |
| Start Date | 2011-05 |
| Est. Completion | 2017-12-31 |
| Phase | Phase 4 |
What the finished NCT02020408 record still lists
NCT02020408 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 88 participants, a relatively small participant target, below the 110-participant average among 9 other Eating Disorder trials with a reported enrollment target (20% lower).
The record links to 1 condition, with Eating Disorder appearing as the primary indexed condition, and to 3 interventions - of which [11C]raclopride is the first listed.
NCT02020408 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT02020408 about?
NCT02020408 is a clinical study titled "Monoamine Contributions to Neurocircuitry in Eating Disorders". This study will use brain imaging technologies to measure several neurotransmitters (serotonin and dopamine) that contribute to our abilities to respond to reward or inhibit our impulses, and which are known to be altered in the brain of people with anorexia nervosa (AN) and bulimia nervosa (BN). Be...
What is the current status of trial NCT02020408?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 88 participants. The study started on 2011-05. Estimated completion is 2017-12-31.
What conditions does trial NCT02020408 study?
This clinical trial studies the following conditions: Eating Disorder.
What interventions are being tested in trial NCT02020408?
The interventions under investigation include: [11C]raclopride (DRUG), [11C]DASB (DRUG), amphetamine (DRUG).
Who is sponsoring clinical trial NCT02020408?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02020408 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Eating Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02020408's enrollment target sits among peer trials
88 4th of 9 higher than 5 of 9 other Eating Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Eating Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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