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NCT01913925 · ClinicalTrials.gov registry record · NA
Effect of Tyrosine Supplementation on Cognitive Performance and Mood During Military Stress
A NA study of Reaction to Severe Stress, Unspecified, sponsored by United States Army Research Institute of Environmental Medicine.
- Completed
- Registry status
- NA
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT01913925 is a NA study of Reaction to Severe Stress, Unspecified that has completed, run by United States Army Research Institute of Environmental Medicine. The registered enrollment target is 80 participants. The trial reports 1 study location across 1 state.
The verdict
NCT01913925, a NA study of Reaction to Severe Stress, Unspecified, has completed, sponsored by United States Army Research Institute of Environmental Medicine.
- COMPLETED
- Registry status
- NA
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
The objective of this research is to determine if tyrosine, an amino acid found in protein-containing foods, will mitigate the cognitive deficits and adverse effects on behavior and mood produced by exposure to military stress. This study was conducted at the US Navy Survive, Evade, Resist, Escape (SERE) school at Brunswick, Maine (ME). Tyrosine is the dietary precursor of the catecholamine norepinephrine, a key brain neurotransmitter that is critical for the central nervous system (CNS) response to various types of acute stress. Psychological stress increases catecholamine turnover in the brain, increasing the requirement for tyrosine to support synthesis of norepinephrine. Animal and human studies have shown that tyrosine supplementation can produce beneficial effects on cognitive and physiological functions during exposure to a variety of acute stressors. This project will determine if volunteers treated with supplemental tyrosine during stressful phases of SERE training experience less degradation in cognitive performance and mood than volunteers treated with placebo. Tyrosine or placebo will be administered in a specially developed food bar provided to volunteers. The bar is part of a prototype of ration-component designed for use during assault operations. A between-subjects, double blind experimental design will be employed. Tyrosine, an amino acid found in most protein-containing foods, has been tested in hundreds of volunteers without adverse effects. Approximately 100 volunteers will be recruited from several SERE classes to ensure up to 80 volunteers complete the study. They will be tested during several portions of SERE. A comprehensive but brief battery of cognitive tests, as well as saliva samples, and heart rate data will be collected in a manner that does not interfere with ongoing training. Hypotheses: 1. Exposure to the stressors of SERE school will adversely impact cognitive performance and mood of volunteers. 2. The adverse effects of psycho
Conditions Studied
Interventions
- OTHER Tyrosine-Containing Food Bar
- OTHER Placebo Bar
Study Locations (1)
Maine
- US Navy SERE School - Brunswick
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2009-07 |
| Est. Completion | 2009-10 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01913925
The ClinicalTrials.gov registry entry for NCT01913925 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is United States Army Research Institute of Environmental Medicine, which has 59 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Reaction to Severe Stress, Unspecified appearing as the primary indexed condition, and to 2 interventions - of which Tyrosine-Containing Food Bar is the first listed.
NCT01913925 reports 1 study location spanning 1 distinct geographic area - top geographies include Maine.
Frequently Asked Questions
What is clinical trial NCT01913925 about?
NCT01913925 is a clinical study titled "Effect of Tyrosine Supplementation on Cognitive Performance and Mood During Military Stress". The objective of this research is to determine if tyrosine, an amino acid found in protein-containing foods, will mitigate the cognitive deficits and adverse effects on behavior and mood produced by exposure to military stress. This study was conducted at the US Navy Survive, Evade, Resist, Escape (...
What is the current status of trial NCT01913925?
This trial is currently completed. It is a NA study. The enrollment target is 80 participants. The study started on 2009-07. Estimated completion is 2009-10.
What conditions does trial NCT01913925 study?
This clinical trial studies the following conditions: Reaction to Severe Stress, Unspecified.
What interventions are being tested in trial NCT01913925?
The interventions under investigation include: Tyrosine-Containing Food Bar (OTHER), Placebo Bar (OTHER).
Who is sponsoring clinical trial NCT01913925?
This trial is sponsored by United States Army Research Institute of Environmental Medicine, which has 59 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01913925 being conducted?
This trial has 1 study location across Maine. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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