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Use of Behavioral Economics to Improve Treatment of Acute Respiratory Infections (Main Study)
NCT01454947 · View on ClinicalTrials.gov ↗
Study Summary
Bacteria resistant to antibiotic therapy are a major public health problem. The evolution of multi-drug resistant pathogens may be encouraged by provider prescribing behavior. Inappropriate use of antibiotics for nonbacterial infections and overuse of broad spectrum antibiotics can lead to the development of resistant strains. Though providers are adequately trained to know when antibiotics are and are not comparatively effective, this has not been sufficient to affect critical provider practices. The intent of this study is to apply behavioral economic theory to reduce the rate of antibiotic prescriptions for acute respiratory diagnoses for which guidelines do not call for antibiotics. Specifically targeted are infections that are likely to be viral. The objective of this study is to improve provider decisions around treatment of acute respiratory infections. The participants are practicing attending physicians or advanced practice nurses (i.e. providers) at participating clinics who see acute respiratory infection patients. A maximum of 550 participants will be recruited for this study. Providers consenting to participate will fill out a baseline questionnaire online. Subsequent to baseline data collection and enrollment, participating clinic sites will be randomized to the study arms, as described below. There will be a control arm, with clinic sites randomized in a multifactorial design to up to three interventions that leverage the electronic medical record: Order Sets that are triggered by electronic health record (EHR) workflow containing exclusively guideline concordant choices (SA, for Suggested Alternatives); Accountable Justifications triggered by discordant prescriptions that populate the note with provider's rationale for guideline exceptions (AJ); and performance feedback that benchmarks providers' own performance to that of their peers (PC, for Peer Comparisons). The outcomes of interest are antibiotic prescribing patterns, including prescribing
Conditions Studied
Interventions
- BEHAVIORAL Clinical Decision Support (CDS): Accountable Justifications
- BEHAVIORAL Audit and Feedback: Peer Comparison
- BEHAVIORAL CDS Order Sets: Suggested Alternatives
Study Locations (20)
California
- Altamed Anaheim Lincoln — Anaheim
- Altamed Anaheim West — Anaheim
- Altamed Bell Clinic — Bell
- Altamed Mobile Unit Primary Care — Commerce
- Altamed DVL El Monte — El Monte
- Altamed El Monte Clinic — El Monte
- Altamed Garden Grove Harbor — Garden Grove
- Altamed Huntington Beach Clinic — Huntington Beach
- Altamed PACE Rugby — Huntington Park
- The Children's Clinic Family Health Center at Cesar Chavez Elementary School — Long Beach
- The Children's Clinic Family Health Center at Hamilton Middle School — Long Beach
- The S. Mark Taper Foundation Children's Clinic Family Health Center — Long Beach
- The Children's Clinic at the Long Beach Multi-Service Center for the Homeless — Long Beach
- The Vasek Polak Children's Clinic Family Health Center — Long Beach
- Altamed PACE Grand Plaza — Los Angeles
- Altamed William Mead Homes — Los Angeles
- Altamed Commerce Clinic — Los Angeles
- Altamed DVL Commerce — Los Angeles
- Altamed PACE Pomona — Los Angeles
- Altamed Boyle Heights Clinic — Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 248 participants |
| Start Date | 2011-08 |
| Est. Completion | 2014-09 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01454947
The ClinicalTrials.gov registry entry for NCT01454947 describes a study currently listed as completed. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 248 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Southern California, which has 412 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Acute Respiratory Infections (ARIs) appearing as the primary indexed condition, and to 3 interventions — of which Clinical Decision Support (CDS): Accountable Justifications is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT01454947 reports 20 study locations spanning 1 distinct geographic area — top geographies include California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT01454947 about?
NCT01454947 is a clinical study titled "Use of Behavioral Economics to Improve Treatment of Acute Respiratory Infections (Main Study)". Bacteria resistant to antibiotic therapy are a major public health problem. The evolution of multi-drug resistant pathogens may be encouraged by provider prescribing behavior. Inappropriate use of antibiotics for nonbacterial infections and overuse of broad spectrum antibiotics can lead to the devel...
What is the current status of trial NCT01454947?
This trial is currently completed. It is a NA study. The enrollment target is 248 participants. The study started on 2011-08. Estimated completion is 2014-09.
What conditions does trial NCT01454947 study?
This clinical trial studies the following conditions: Acute Respiratory Infections (ARIs). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT01454947?
The interventions under investigation include: Clinical Decision Support (CDS): Accountable Justifications (BEHAVIORAL), Audit and Feedback: Peer Comparison (BEHAVIORAL), CDS Order Sets: Suggested Alternatives (BEHAVIORAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT01454947?
This trial is sponsored by University of Southern California, which has 412 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT01454947 being conducted?
This trial has 20 study locations across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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