Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00980980 · ClinicalTrials.gov registry record · NA
Cluster Randomized Trial of Hospitals to Assess Impact of Targeted Versus Universal Strategies to Reduce Methicillin-resistant Staphylococcus Aureus (MRSA) in Intensive Care Units (ICUs)
A NA study of Methicillin-resistant Staphylococcus Aureus, sponsored by Harvard Pilgrim Health Care.
- Completed
- Registry status
- NA
- Development phase
- 74,256
- Enrollment target
- 20
- Study locations
NCT00980980: Completed NA study of Methicillin-resistant Staphylococcus Aureus, sponsored by Harvard Pilgrim Health Care.
NCT00980980 is a NA study of Methicillin-resistant Staphylococcus Aureus that has completed, run by Harvard Pilgrim Health Care. The registered enrollment target is 74,256 participants, above the 1,054-participant average among 5 other Methicillin-resistant Staphylococcus Aureus trials with a reported enrollment target (6945% higher). The trial reports 20 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00980980, a NA study of Methicillin-resistant Staphylococcus Aureus, has completed, sponsored by Harvard Pilgrim Health Care.
- COMPLETED
- Registry status
- NA
- Development phase
- 74,256 participants
- Enrollment target
- 20
- Study locations
Study Summary
The Randomized Evaluation of Decolonization versus Universal Clearance to Eliminate MRSA (REDUCE MRSA) Trial is a cluster randomized trial of the comparative effectiveness of three strategies to prevent methicillin-resistant Staphylococcus aureus (MRSA) in intensive care units. The three strategies to be evaluated are: * screening on admission followed by isolation of MRSA+ patients * screening on admission followed by isolation and decolonization of MRSA+ patients * universal decolonization on admission with no screening. The decolonization regimen involves bathing with chlorhexidine plus intra-nasal application of mupirocin. The main outcome will be MRSA+ clinical cultures. The study is a partnership between the CDC, the CDC Prevention Epicenters, and the Hospital Corporation of America.
Primary Outcome
Hazard ratio for ICU-attributable MRSA+ clinical cultures comparing Baseline to Intervention period, by Arm, accounting for clustering by hospital.
Conditions Studied
Interventions
- DRUG Chlorhexidine bath and nasal mupirocin
Study Locations (20)
Florida
- Blake Medical Center - Brandenton
- Brandon Hospital - Brandon
- Columbia Hosp Corp S Broward (Westside) - Fort Lauderdale
- Palms West Hospital - Fort Lauderdale
- Plantation General - Fort Lauderdale
- Regional Med Cr Bayonet Point - Hudson
- Largo Medical Center - Largo
- Community Hospital - New Port Richey
- Orange Park Med Ctr - Orange Park
- Fawcett Memorial Hospital - Port Charlotte
- Doctors Hospital of Sarasota - Sarasota
- South Bay Hospital - Sun City Center
- Capital Regional Med Ctr - Tallahassee
Georgia
- Coliseum (Macon) Northside - Macon
- Coliseum Medical Center - Macon
- Cartersville Medical Center - Tucker
Alaska
- Alaska Regional - Anchorage
California
- Los Robles Hosp & Med Ctr - Thousand Oaks
Colorado
- The Medical Center of Aurora - Aurora
Idaho
- Eastern Idaho Reg Med Ctr - Idaho Falls
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 74,256 participants |
| Start Date | 2009-09 |
| Est. Completion | 2011-09 |
| Phase | NA |
What the finished NCT00980980 record still lists
NCT00980980 is an interventional study that assigns participants to a tested intervention. Its 74,256 participants enrollment target places it among the larger protocols in the corpus, above the 1,054-participant average among 5 other Methicillin-resistant Staphylococcus Aureus trials with a reported enrollment target (6945% higher).
The record links to 1 condition, with Methicillin-resistant Staphylococcus Aureus appearing as the primary indexed condition, and to 1 intervention - of which Chlorhexidine bath and nasal mupirocin is the first listed.
NCT00980980 names 20 study sites across 6 states, led by Florida, Georgia, Alaska.
Frequently Asked Questions
What is clinical trial NCT00980980 about?
NCT00980980 is a clinical study titled "Cluster Randomized Trial of Hospitals to Assess Impact of Targeted Versus Universal Strategies to Reduce Methicillin-resistant Staphylococcus Aureus (MRSA) in Intensive Care Units (ICUs)". The Randomized Evaluation of Decolonization versus Universal Clearance to Eliminate MRSA (REDUCE MRSA) Trial is a cluster randomized trial of the comparative effectiveness of three strategies to prevent methicillin-resistant Staphylococcus aureus (MRSA) in intensive care units. The three strategies ...
What is the current status of trial NCT00980980?
This trial is currently completed. It is a NA study. The enrollment target is 74,256 participants. The study started on 2009-09. Estimated completion is 2011-09.
What conditions does trial NCT00980980 study?
This clinical trial studies the following conditions: Methicillin-resistant Staphylococcus Aureus.
What interventions are being tested in trial NCT00980980?
The interventions under investigation include: Chlorhexidine bath and nasal mupirocin (DRUG).
Who is sponsoring clinical trial NCT00980980?
This trial is sponsored by Harvard Pilgrim Health Care, which has 28 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00980980 being conducted?
This trial has 20 study locations across Alaska, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Methicillin-resistant Staphylococcus Aureus
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
PMT for MDRO Decolonization
RECRUITING · Phase 2
-
Trimethoprim-sulfamethoxazole vs. Clindamycin for the Treatment of Children With Invasive MRSA Infections
RECRUITING · Phase 4
-
Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus Aureus
COMPLETED
-
Comparison of Bacterial Contamination Rates Between Isolation and Non-isolation Rooms
COMPLETED
-
Primary Care Management of Community-Acquired, Methicillin-Resistant Staphylococcus Aureus (CA-MRSA) Infections
COMPLETED
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02402244 · 75,000 participants
Project: Every Child for Younger Patients With Cancer
- NCT02803242 · 75,000 participants
COPD Patient-Powered Research Network
- NCT04611568 · 75,000 participants · NA
War on Melanoma™ Public Health & Education Campaign
- NCT00063063 · 80,000 participants
Generic Database of Very Low Birth Weight Infants
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia