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Aprepitant + a 5HT3 + Dexamethasone in Patients With Germ Cell Tumors
NCT00572572 · View on ClinicalTrials.gov ↗
Study Summary
Aprepitant is currently approved for prophylaxis of acute and delayed CINV for highly emetogenic chemotherapy regimens, including cisplatin; however, it has not yet been studied in multiple-day chemotherapy treatment programs. This study will compare the addition of aprepitant compared to placebo administered on days 3,4,5 of chemotherapy administration for acute CINV prophylaxis with standard antiemetic prophylaxis and days 6 and 7 for delayed CINV prophylaxis in a double-blind, randomized, crossover study design.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Aprepitant
Study Locations (6)
Indiana
- Indiana University Simon Cancer Center — Indianapolis
- Medical Consultants, P.C. — Muncie
Missouri
- Siteman Cancer Center — St Louis
Oregon
- Providence Portland Medical Center — Portland
Pennsylvania
- University of Pennsylvania — Philadelphia
Wisconsin
- Froedtert/Medical College of Wisconsin — Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 69 participants |
| Start Date | 2007-12 |
| Est. Completion | 2011-02 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00572572
The ClinicalTrials.gov registry entry for NCT00572572 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 69 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoosier Cancer Research Network, which has 4 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Germ Cell Tumors appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00572572 reports 6 study locations spanning 5 distinct geographic areas — top geographies include Indiana, Missouri, Oregon. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00572572 about?
NCT00572572 is a clinical study titled "Aprepitant + a 5HT3 + Dexamethasone in Patients With Germ Cell Tumors". Aprepitant is currently approved for prophylaxis of acute and delayed CINV for highly emetogenic chemotherapy regimens, including cisplatin; however, it has not yet been studied in multiple-day chemotherapy treatment programs. This study will compare the addition of aprepitant compared to placebo ad...
What is the current status of trial NCT00572572?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 69 participants. The study started on 2007-12. Estimated completion is 2011-02.
What conditions does trial NCT00572572 study?
This clinical trial studies the following conditions: Germ Cell Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00572572?
The interventions under investigation include: Placebo (DRUG), Aprepitant (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00572572?
This trial is sponsored by Hoosier Cancer Research Network, which has 4 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00572572 being conducted?
This trial has 6 study locations across Indiana, Missouri, Oregon, Pennsylvania, Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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