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COMPLETED Phase 3

A Study Evaluating Intravenous (IV) MOA-728 for the Treatment of Postoperative Ileus (POI) in Participants After Ventral Hernia Repair

NCT00528970 · View on ClinicalTrials.gov ↗

Study Summary

This study will evaluate the safety and efficacy of two different dose regimens (12 milligrams \[mg\] and 24 mg) of IV MOA-728 versus placebo in shortening the time to return of bowel function in participants receiving opioid analgesia administered via patient-controlled anesthesia (PCA), and who had undergone repair of large (greater than or equal to \[≥\]10 centimeters) ventral hernias with or without a mesh prosthesis via laparotomy or laparoscopy.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG MOA-728

Study Locations (20)

Florida

  • — Inverness
  • — Jacksonville
  • — Jacksonville
  • — Melbourne
  • — Miami
  • — Miami
  • — Naples
  • — Orlando
  • — Pensacola

California

  • — Colton
  • — Laguna Hills
  • — Loma Linda
  • — Long Beach
  • — Los Angeles
  • — Orange
  • — San Jose
  • — Santa Barbara

Colorado

  • — Denver
  • — Denver

Arkansas

  • — Benton

Trial Details

FieldValue
Enrollment Target 374 participants
Start Date 2007-10-17
Est. Completion 2008-02-05
Phase Phase 3

Sponsor

Bausch Health Americas

55 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00528970

The ClinicalTrials.gov registry entry for NCT00528970 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 374 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Bausch Health Americas, which has 55 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Ileus appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00528970 reports 20 study locations spanning 4 distinct geographic areas — top geographies include Florida, California, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00528970 about?

NCT00528970 is a clinical study titled "A Study Evaluating Intravenous (IV) MOA-728 for the Treatment of Postoperative Ileus (POI) in Participants After Ventral Hernia Repair". This study will evaluate the safety and efficacy of two different dose regimens (12 milligrams \[mg\] and 24 mg) of IV MOA-728 versus placebo in shortening the time to return of bowel function in participants receiving opioid analgesia administered via patient-controlled anesthesia (PCA), and who ha...

What is the current status of trial NCT00528970?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 374 participants. The study started on 2007-10-17. Estimated completion is 2008-02-05.

What conditions does trial NCT00528970 study?

This clinical trial studies the following conditions: Ileus. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00528970?

The interventions under investigation include: Placebo (DRUG), MOA-728 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00528970?

This trial is sponsored by Bausch Health Americas, which has 55 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00528970 being conducted?

This trial has 20 study locations across Arkansas, California, Colorado, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial