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COMPLETED Phase 3

Multicenter Study of Antiarrhythmic Medications for Treatment of Infants With Supraventricular Tachycardia

NCT00390546 · View on ClinicalTrials.gov ↗

Study Summary

This is a randomized, double-blind, multi-centered study to compare 6 months of medical treatment with digoxin or propranolol in infants with SVT Background: SVT is the most common sustained arrhythmia of infancy. Neither digoxin nor propranolol has been evaluated for pediatric use in a controlled trial in the context of SVT, yet both medications are used frequently. Specific aims of the study: To determine whether propranolol and digoxin differ in the: 1. Incidence of recurrent SVT in infants after 6 months of treatment with propranolol or digoxin 2. Time to first recurrence of SVT in infants treated with propranolol or digoxin. 3. Incidence of adverse outcomes in infants treated with propranolol or digoxin.

Interventions

  • DRUG Propranolol
  • DRUG Digoxin

Study Locations (14)

California

  • University of Southern California - Children's Hospital of Los Angeles — Los Angeles
  • Children's Hospital of Orange County — Orange

Missouri

  • The Children's Mercy Hospital — Kansas City

New York

  • Schneider Children's Hospital — New Hyde Park

North Carolina

  • Duke University Medical Center — Durham

Ohio

  • Nationwide Children's Hospital Ohio — Columbus

South Carolina

  • Medical University of Charleston South Carolina — Charleston

Utah

  • Primary Children's Medical Centre — Salt Lake City

Virginia

  • Norfolk Children's Hospital of the King's Daughter's — Norfolk

Trial Details

FieldValue
Enrollment Target 72 participants
Start Date 2006-10
Est. Completion 2011-08
Phase Phase 3

Sponsor

University of British Columbia

8 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00390546

The ClinicalTrials.gov registry entry for NCT00390546 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 72 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of British Columbia, which has 8 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Supraventricular Tachycardia appearing as the primary indexed condition, and to 2 interventions — of which Propranolol is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00390546 reports 14 study locations spanning 13 distinct geographic areas — top geographies include California, Missouri, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00390546 about?

NCT00390546 is a clinical study titled "Multicenter Study of Antiarrhythmic Medications for Treatment of Infants With Supraventricular Tachycardia". This is a randomized, double-blind, multi-centered study to compare 6 months of medical treatment with digoxin or propranolol in infants with SVT Background: SVT is the most common sustained arrhythmia of infancy. Neither digoxin nor propranolol has been evaluated for pediatric use in a controlled t...

What is the current status of trial NCT00390546?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 72 participants. The study started on 2006-10. Estimated completion is 2011-08.

What conditions does trial NCT00390546 study?

This clinical trial studies the following conditions: Supraventricular Tachycardia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00390546?

The interventions under investigation include: Propranolol (DRUG), Digoxin (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00390546?

This trial is sponsored by University of British Columbia, which has 8 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00390546 being conducted?

This trial has 14 study locations across California, Missouri, New York, North Carolina, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial