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NCT00021437 · ClinicalTrials.gov registry record
Biological Significance of the Bloom's Syndrome Protein
A clinical trial of Bloom Syndrome, sponsored by National Center for Research Resources (NCRR).
- Completed
- Registry status
- 1
- Study location
NCT00021437: Completed study of Bloom Syndrome, sponsored by National Center for Research Resources (NCRR).
NCT00021437 is a study of Bloom Syndrome that has completed, run by National Center for Research Resources (NCRR). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00021437, a study of Bloom Syndrome, has completed, sponsored by National Center for Research Resources (NCRR).
- COMPLETED
- Registry status
- 1
- Study location
Study Summary
Since 1960, persons with the very rare disorder Bloom's syndrome (BS) have been followed clinically, documenting clinical matters as obtained from their doctors. This has been a worldwide search for cases, though a few in the New York City area are seen (personally, by us) perhaps once every 2-3 years. BS is a rare genetically-determined disorder described in NYC in 1954. The clinical courses of the 169 persons diagnosed BS by 1991 are followed in a program referred to as the Bloom's Syndrome Registry. BS is the prototype of the "chromosome-breakage syndromes." BS cells mutate at a greater rate than any other, and the consequence is the greatest known predisposition to cancers of the types that affect the general human population. We are defining the clinical syndrome and at the same time are studying cells from affected families in the experimental laboratory. BS is a model for learning about cancer. Our contact with families lets us know of cancers arising, but blood, and sometimes tiny biopsies of skin, is taken if available so that (a) the chromosomes can be studied and (b) the gene mutations can be defined in molecular terms.
Conditions Studied
Study Locations (1)
New York
- New York Hospital-Cornell Medical Center - New York
Trial Details
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What the finished NCT00021437 record still lists
NCT00021437 is an observational study that tracks outcomes without assigning an intervention. An enrollment target was not published in the registry record, which is common for early-stage or observational entries.
The record links to 1 condition, with Bloom Syndrome appearing as the primary indexed condition, and to 0 interventions.
NCT00021437 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT00021437 about?
NCT00021437 is a clinical study titled "Biological Significance of the Bloom's Syndrome Protein". Since 1960, persons with the very rare disorder Bloom's syndrome (BS) have been followed clinically, documenting clinical matters as obtained from their doctors. This has been a worldwide search for cases, though a few in the New York City area are seen (personally, by us) perhaps once every 2-3 yea...
What is the current status of trial NCT00021437?
This trial is currently completed.
What conditions does trial NCT00021437 study?
This clinical trial studies the following conditions: Bloom Syndrome.
Who is sponsoring clinical trial NCT00021437?
This trial is sponsored by National Center for Research Resources (NCRR), which has 94 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00021437 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.