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NCT00000717 · ClinicalTrials.gov registry record · NA

The Safety and Efficacy of Clindamycin and Primaquine in the Treatment of Mild - Moderate Pneumocystis Carinii Pneumonia in Patients With AIDS

A NA study of HIV Infections and Pneumonia, Pneumocystis Carinii, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).

Completed
Registry status
NA
Development phase
50
Enrollment target
7
Study locations

NCT00000717: Completed NA study of HIV Infections and Pneumonia, Pneumocystis Carinii, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).

NCT00000717 is a NA study of HIV Infections and Pneumonia, Pneumocystis Carinii that has completed, run by National Institute of Allergy and Infectious Diseases (NIAID). The registered enrollment target is 50 participants, below the 446-participant average among 542 other HIV Infections trials with a reported enrollment target (89% lower). The trial reports 7 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT00000717, a NA study of HIV Infections and Pneumonia, Pneumocystis Carinii, has completed, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).

COMPLETED
Registry status
NA
Development phase
50 participants
Enrollment target
7
Study locations

Study Summary

To determine the safety and effectiveness of clindamycin and primaquine in the treatment of mild Pneumocystis carinii pneumonia (PCP) in AIDS patients. As many as 80 percent of AIDS patients experience at least one episode of PCP and about one-third of these patients have a recurrence of the disease. Drugs currently used for treatment of acute PCP are toxic to the majority of AIDS patients. The combination of clindamycin and primaquine reduces the numbers of PCP organisms in laboratory tests and in animal studies. Both drugs can be given orally, concentrate in lung tissue, and have been used safely in humans for treatment of other diseases. It is possible that the combination may prove to be as good or better than standard therapy for PCP and side effects may be less.

Conditions Studied

HIV Infections Pneumonia, Pneumocystis Carinii

Interventions

  • DRUG Clindamycin
  • DRUG Primaquine

Study Locations (7)

California

  • Los Angeles County - USC Med Ctr - Los Angeles
  • San Francisco AIDS Clinic / San Francisco Gen Hosp - San Francisco

Illinois

  • Northwestern Univ Med School - Chicago
  • Rush Presbyterian - Saint Luke's Med Ctr - Chicago

Ohio

  • Univ Hosp of Cleveland / Case Western Reserve Univ - Cleveland
  • Ohio State Univ Hosp Clinic - Columbus

Indiana

  • Indiana Univ Hosp - Indianapolis

Trial Details

FieldValue
Enrollment Target 50 participants
Est. Completion 1991-11
Phase NA
National Institute of Allergy and Infectious Diseases (NIAID)

2,006 total trials

What the finished NCT00000717 record still lists

NCT00000717 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 446-participant average among 542 other HIV Infections trials with a reported enrollment target (89% lower).

The record links to 2 conditions, with HIV Infections appearing as the primary indexed condition, and to 2 interventions - of which Clindamycin is the first listed.

NCT00000717 lists 7 locations in 4 states (California, Illinois, Ohio).

Frequently Asked Questions

What is clinical trial NCT00000717 about?

NCT00000717 is a clinical study titled "The Safety and Efficacy of Clindamycin and Primaquine in the Treatment of Mild - Moderate Pneumocystis Carinii Pneumonia in Patients With AIDS". To determine the safety and effectiveness of clindamycin and primaquine in the treatment of mild Pneumocystis carinii pneumonia (PCP) in AIDS patients. As many as 80 percent of AIDS patients experience at least one episode of PCP and about one-third of these patients have a recurrence of the diseas...

What is the current status of trial NCT00000717?

This trial is currently completed. It is a NA study. The enrollment target is 50 participants. Estimated completion is 1991-11.

What conditions does trial NCT00000717 study?

This clinical trial studies the following conditions: HIV Infections, Pneumonia, Pneumocystis Carinii.

What interventions are being tested in trial NCT00000717?

The interventions under investigation include: Clindamycin (DRUG), Primaquine (DRUG).

Who is sponsoring clinical trial NCT00000717?

This trial is sponsored by National Institute of Allergy and Infectious Diseases (NIAID), which has 2,006 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00000717 being conducted?

This trial has 7 study locations across California, Illinois, Indiana, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for HIV Infections

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT00000717's enrollment target sits among peer trials

50 355th of 542 higher than 177 of 542 other HIV Infections trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other HIV Infections trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT00000717, the US trial registry maintained by the National Library of Medicine. NCT00000717 (small enrollment · multi site footprint · completed) retrieved and formatted by PlainTrial, see methodology.