Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Restless Legs Syndrome: early-phase trial registry
1 of 15 indexed Restless Legs Syndrome trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1,140 of 28,707 conditions by registered trial count.
15 US clinical trials · 1 currently recruiting · #1,140 of 28,707 conditions by registered trial count
Restless Legs Syndrome: 15 US clinical trials tracked, 1 recruiting.
Restless Legs Syndrome is the subject of 15 registered US clinical trials on ClinicalTrials.gov, 1 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Noctrix Health, running 4 of these trials.
Enrollment posture brief
Registry condition restless-legs-syndrome
OPEN 1 | RECR 7% | LATE 3 | EARLY 5 | RANK #1140 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Liver Disease (7% recruiting · 15 trials)
Restless Legs Syndrome lists 1 open slots (7% of 15 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Restless Legs Syndrome on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Restless Legs Syndrome is recruiting below its size-band peers.
1 of 15 indexed trials (6.7%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Restless Legs Syndrome research.
Noctrix Health accounts for 4 of 15 trials (26.7%). 9 distinct sponsors appear on at least one study for this condition label.
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Most Restless Legs Syndrome trials plan to enrol fewer than 100 people.
Median target enrolment is 48 among the 15 trials that report a genuine target (sentinel values excluded). 11 of those (73.3%) plan for fewer than 100 participants.
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Restless Legs Syndrome research is mostly interventional.
13 interventional and 2 observational studies make up this index (86.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
15 total, page 1 of 1
Blood Changes After Exercise in Restless Legs Syndrome
Stanford University
NCT06481176
A Post-Market Study for Long-Term Effectiveness and Safety of the NTX100 for RLS
Noctrix Health
NCT06076499
Treating Leg Symptoms in Women With X-linked Adrenoleukodystrophy
Massachusetts General Hospital
NCT05003648
Response to an Investigational Device in Patients With Restless Legs Syndrome
Noctrix Health
NCT06866132
Benefits of a Cannabidiolic Acid Topical Cream for the Treatment of Restless Leg Syndrome
Synthonics
NCT06570941
A Clinical Research Study Testing Ropinirole Treatment for Restless Legs Syndrome
GlaxoSmithKline
NCT00363857
Noninvasive Peripheral Nerve Stimulation for Medication-Refractory Primary RLS (The RESTFUL Study)
Noctrix Health
NCT04874155
Simulated Driving Study in Restless Legs Syndrome
XenoPort
NCT01332318
Suggested Immobilization Test (SIT) Test for Early Detection of Restless Legs Syndrome (RLS) Augmentation - Proof of Concept
Johns Hopkins University
NCT00867893
Bupropion and Restless Legs Syndrome
East Tennessee State University
NCT00621517
A Study to Evaluate the Effect of Gabapentin on Cardiac Repolarization in Healthy Volunteers
XenoPort
NCT01516372
A Study To Investigate The Effects Of End Stage Renal Disease And Hemodialysis On The Pharmacokinetics Of Ropinirole
GlaxoSmithKline
NCT00422994
12-week Polysomnography Study of Ropinirole Controlled Release for Restless Legs Syndrome
GlaxoSmithKline
NCT00373542
A Study on the Use of the MMF07 Foot Massager and Heat Therapy Treatments for Restless Leg Syndrome
Ariane Park
NCT02526277
Noninvasive Peripheral Nerve Stimulation for Restless Legs Syndrome During Opioid Medication Reduction
Noctrix Health
NCT04698343
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 2 |
| Phase 3 | 1 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Restless Legs Syndrome records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Restless Legs Syndrome trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Restless Legs Syndrome page
15 registered trials, 1 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 1 Restless Legs Syndrome trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Noctrix Health sponsors the most Restless Legs Syndrome trials on record, review their full trial history before evaluating a specific study. See Noctrix Health's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Restless Legs Syndrome condition card totals 15 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.