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ClinicalTrials.gov 1 recruiting now official registry

Restless Legs Syndrome clinical trials

1 of 15 indexed Restless Legs Syndrome trials are currently recruiting.

15 US clinical trials · 1 currently recruiting

Restless Legs Syndrome is the subject of 15 registered US clinical trials on ClinicalTrials.gov, 1 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Noctrix Health, running 4 of these trials.

The research picture

Restless Legs Syndrome has 15 registered US clinical trials, 1 of them open to new participants right now, about 7% of the total.

1
recruiting participants now
7%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
4
top sponsor: Noctrix Health
Phase 13Phase 22Phase 31Phase 42

Active & Recent Trials

15 total, page 1 of 1

RECRUITING NA 30 participants

Blood Changes After Exercise in Restless Legs Syndrome

Stanford University

NCT06481176

ACTIVE NOT RECRUITING 325 participants

A Post-Market Study for Long-Term Effectiveness and Safety of the NTX100 for RLS

Noctrix Health

NCT06076499

ACTIVE NOT RECRUITING Phase 4 24 participants

Treating Leg Symptoms in Women With X-linked Adrenoleukodystrophy

Massachusetts General Hospital

NCT05003648

ACTIVE NOT RECRUITING NA 20 participants

Response to an Investigational Device in Patients With Restless Legs Syndrome

Noctrix Health

NCT06866132

ACTIVE NOT RECRUITING Phase 1 10 participants

Benefits of a Cannabidiolic Acid Topical Cream for the Treatment of Restless Leg Syndrome

Synthonics

NCT06570941

COMPLETED Phase 3 360 participants

A Clinical Research Study Testing Ropinirole Treatment for Restless Legs Syndrome

GlaxoSmithKline

NCT00363857

COMPLETED NA 133 participants

Noninvasive Peripheral Nerve Stimulation for Medication-Refractory Primary RLS (The RESTFUL Study)

Noctrix Health

NCT04874155

COMPLETED Phase 2 130 participants

Simulated Driving Study in Restless Legs Syndrome

XenoPort

NCT01332318

COMPLETED 68 participants

Suggested Immobilization Test (SIT) Test for Early Detection of Restless Legs Syndrome (RLS) Augmentation - Proof of Concept

Johns Hopkins University

NCT00867893

COMPLETED Phase 2 60 participants

Bupropion and Restless Legs Syndrome

East Tennessee State University

NCT00621517

COMPLETED Phase 1 52 participants

A Study to Evaluate the Effect of Gabapentin on Cardiac Repolarization in Healthy Volunteers

XenoPort

NCT01516372

COMPLETED Phase 1 48 participants

A Study To Investigate The Effects Of End Stage Renal Disease And Hemodialysis On The Pharmacokinetics Of Ropinirole

GlaxoSmithKline

NCT00422994

COMPLETED Phase 4 39 participants

12-week Polysomnography Study of Ropinirole Controlled Release for Restless Legs Syndrome

GlaxoSmithKline

NCT00373542

COMPLETED NA 28 participants

A Study on the Use of the MMF07 Foot Massager and Heat Therapy Treatments for Restless Leg Syndrome

Ariane Park

NCT02526277

COMPLETED NA 21 participants

Noninvasive Peripheral Nerve Stimulation for Restless Legs Syndrome During Opioid Medication Reduction

Noctrix Health

NCT04698343

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 2
Phase 3 1
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Restless Legs Syndrome Trial Landscape

15 indexed Restless Legs Syndrome studies · 1 recruiting (7%).

Phase mix: 3 late (III/IV) vs 5 early (I/II).

Top sponsor: Noctrix Health (4 trials), 8 others listed. 15 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Restless Legs Syndrome?

PlainTrial tracks 15 US clinical trials for Restless Legs Syndrome, of which 1 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Restless Legs Syndrome?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.