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ClinicalTrials.gov 5 recruiting now official registry

B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative clinical trials

Every US clinical trial registered for B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

7 US clinical trials · 5 currently recruiting

The research picture

B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative has 7 registered US clinical trials, 5 of them open to new participants right now — about 71% of the total.

5
recruiting participants now
71%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
3
top sponsor: National Cancer Institute (NCI)

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 1 276 participants

Inotuzumab Ozogamicin and Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia

M.D. Anderson Cancer Center

NCT01371630

RECRUITING Phase 2 64 participants

Inotuzumab Ozogamicin and Blinatumomab With or Without Ponatinib in Treating Patients With Newly Diagnosed, Recurrent, or Refractory CD22-Positive B-Lineage Acute Lymphoblastic Leukemia

National Cancer Institute (NCI)

NCT03739814

RECRUITING Phase 2 53 participants

Asparaginase Erwinia Chrysanthemi With Chemotherapy for the Treatment of High-Risk Adults With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

City of Hope Medical Center

NCT06918431

RECRUITING Phase 2 30 participants

Chemotherapy (DA-EPOCH+/-R) and Targeted Therapy (Tafasitamab) for the Treatment of Newly-Diagnosed Philadelphia Chromosome Negative B Acute Lymphoblastic Leukemia

University of Washington

NCT05453500

RECRUITING Phase 2 30 participants

Etoposide, Prednisone, Vincristine, Cyclophosphamide, and Doxorubicin (DA-EPOCH) With or Without Rituximab Plus Recombinant Erwinia Asparaginase (JZP458) for the Treatment of Newly Diagnosed Ph Negative B-Acute Lymphoblastic Leukemia or T Acute Lymphoblastic Leukemia

University of Washington

NCT06738368

ACTIVE NOT RECRUITING Phase 3 488 participants

Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia

National Cancer Institute (NCI)

NCT02003222

COMPLETED Phase 2 16 participants

Sapanisertib in Treating Patients With Relapsed and/or Refractory Acute Lymphoblastic Leukemia

National Cancer Institute (NCI)

NCT02484430

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 5
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative Trial Landscape

ClinicalTrials.gov lists 7 US studies indexed under B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative, and 5 of those are currently open to recruitment — roughly 71% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 6 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative is led by National Cancer Institute (NCI) with 3 indexed trials, alongside 3 other organizations in the top contributor list. The list on this page surfaces up to 7 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative?

PlainTrial tracks 7 US clinical trials for B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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